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431 The upregulation of mTOR in diseases has profound effects on mitochondria (Fig

On the contrary, in anemic conditions where the number of circulating RBCs is decreased without concomitant hemolysis, a decrease of RBC-dependent scavenging of NO may instead increase systemic NO bioavailability and cause vasodilation, increased flow, and may affect cardiovascular hemodynamics (140)

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This in turn results in oxidative damage, lipid peroxidation, and cellular dysfunction

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Supramolecular nanoparticle loaded with bilirubin enhances cartilage protection and alleviates osteoarthritis via modulating oxidative stress and inflammatory responses