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Since a maxim in nutrition is that intake does not equal absorption and multiple factors influence absorption, not everyone will have the same absorption/yield of nutrients, and in the case of B12, the theoretical amounts were initially established to prevent megaloblastic anemia, but perhaps not to ensure that everyone has a good status, and not everyone has the same absorption or the same chrononutritional distribution

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However, the duration of relief varies from person to person, and the injections may need to be repeated periodically for long-term management of chronic conditions