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The Journal of biological chemistry 256, 12387- 12392

In contrast to acute use of sulfonylureas, chronic use results in improved blood glucose control, but with less rather than more insulin secretion (78)

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Kraemer MU, Sinka ME, Duda KA, Mylne A, Shearer FM, Brady OJ, et al

Anti-inflammatory pathways of -MSH peptides.Endocrine Reviews(2010)

However, due to the differences in clinical scenarios and research objects, the cut-off values of the above indicators are still difficult to be determined, and RCT experiments with a larger sample size are needed for further verification