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Probing mechanisms and therapeutic potential of -secretase in Alzheimers Disease

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Shvarev D, Schoppe J, Knig C, Perz A, Fllbrunn N, Kiontke S, Langemeyer L, Januliene D, Schnelle K, Kmmel D, Frhlich F, Moeller A, Ungermann C (2022) Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery

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The application of autophagy-related molecules as therapeutic targets to counteract DOR is still in its early stages and warrants additional research to clarify both their therapeutic potential and associated risks