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AOD-9604 demonstrates selectivity for beta-3 receptors, which are predominantly expressed in adipose tissue

50mg produces approximately 4050% enzyme inhibition, while 100mg achieves 6075% inhibition, but the curve plateaus beyond 150mg, suggesting diminishing returns

DGAT enzymes and triacylglycerol biosynthesis

This occurs through multiple mechanisms

Especially preferred heteroaryl groups include 1,2,3-triazole, 1,2,4-triazole, 5-1,2,4-triazole, imidazole, oxazole, isoxazole, 1,2,3-oxadiazole, 1,2,4-oxadiazole, 3-amino-1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole, pyridine, and 2-aminopyridine.amino The term heterocycle or heterocyclic ring, as used herein except where noted, represents a stable 5- to 7-membered monocyclic-, or stable 7- to 11-membered bicyclic heterocyclic ring system, any ring of which may be saturated or unsaturated, and which consists of carbon atoms and from one to three heteroatoms selected from the group consisting of N, O and S, and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen heteroatom may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring