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In animal reproduction studies, daily subcutaneous administration of zoledronic acid to pregnant rats during organogenesis resulted in increases in fetal skeletal, visceral, and external malformations, decreases in postimplantation survival, and decreases in viable fetuses and fetal weight starting at doses equivalent to 2 times the recommended human 5 mg intravenous dose (based on AUC)

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Sermorelins body composition effects are real but typically smaller, partly because the GH pulse is briefer and partly because the single-pathway mechanism produces less amplitude than dual activation