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Mitochondrial introduction from exogenous sources may reverse the Warburg effect and promote cell death under therapeutic stress [478]

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In parallel, microbial PAMPs and TLR signaling pathways activate IRF8 through MyD88 and TRIF adaptors, linking pathogen recognition to autophagic defense

Lactobacillus plantarum reduces Streptococcus pyogenes virulence by modulating the IL-17, IL-23 and Toll-like receptor 2/4 expressions in human epithelial cells

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9 , 10 This may help explain why cortical cataracts are more common in African-Americans compared with Caucasians who are exposed to the same risk factors