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10.1007/s00726-011-0867-5 18 DingY.ChenX.LiuC.GeW.WangQ.HaoX.et al (2021)

FIGURE 6 In conclusion, the pathogenesis of type 1 diabetes involves the immune-mediated destruction of -cells and abnormal activation of immune cells, with macrophage polarization playing a critical role in immune regulation, making it a promising therapeutic target