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Journal of Metabolic Research , 45(3), 217225

However, improved energy levels may help some people become more active. Any weight change is indirect and related to increased activity, not fat loss caused by the injection

The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis