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It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances (Sanjay et al., 2022

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Homeostatic control of zinc metabolism in men: Zinc excretion and balance in men fed diets low in zinc

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In conclusion, further investigation is warranted to elucidate the underlying pathways and regulatory mechanisms associated with ferroptosis in PF