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These dual roles highlight the metabolic and immunologic plasticity of tryptophan in pulmonary fibrosis and suggest that selective modulation of its downstream pathways may offer promising antifibrotic strategies

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doi: 10.2306/scienceasia1513-1874.2008.34.327 93 Clavero-SalasASotelo-MundoRGollas-GalvanTHernandez-LopezJPeregrino-UriarteAMuhlia-AlmazanAet al

It reduces oxidative stress by scavenging free radicals (35, 36) and suppresses inflammatory and pro-inflammatory cytokines (e.g., TNF- , IL-6) (37), offering promise in managing chronic inflammatory conditions such as arthritis and metabolic disorders

Their findings suggest that MT enhances the antioxidant activity of Volvariella volvacea through processes such as amino acid metabolism, glutathione metabolism, redox reactions, detoxification, and cellular oxidant detoxification, indicating that exogenous MT can shield edible mushrooms from Cd-induced oxidative stress