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One study, which also evaluated cognitive function in patients with high MMA concentrations, found no significant effects on the MDD inventory score, but only 30 of the 140 subjects had depression at baseline, which may have diluted any benefits

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The hypothesis of acupuncture neuroimmune regulation in the IS model by eliciting the vagaladrenal and spinalsympathetic axes has been raised

However, it is important to note that hydroxocobalamin is not effective in treating pernicious anemia, which is caused by an autoimmune disorder