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Oral methioninase inhibits recurrence in a PDOX mouse model of aggressive triple-negative breast cancer

Hongqing Zhou (zhouhongqing

2016;11(11):e0163716

Glucose-6-phosphate dehydrogenase (G6PD) is the rate limiting enzyme in PPP (Jain et al., 2004), and therefore, the level of G6PD would also determine the flux of PPP and the generation rate of NADPH (Li et al., 2014)

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Furthermore, ACA suppressed the expression of Th2 cytokines (IL-4, IL-6, and IL-13) and Th1 cytokines (IL-12 and IFN-) in the ACA-treated group in a dose-dependent manner