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Caffeic acid-conjugated budesonide-loaded nanomicelle attenuates inflammation in experimental colitis

Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC gastroenterology 17.1 (2017): 96

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The first evidence came from the Framingham Heart Study in 1966 demonstrating a link between HDL-C and ASCVD (713)

The renoprotective effect of FXR is mainly mediated by regulating lipid metabolism, oxidative stress, pro-inflammatory cytokines, and pro-fibrotic factors, thus inhibiting the increased proteinuria, podocyte loss, mesangial expansion and renal lipid accumulation (Masaoutis and Theocharis, 2019)

The permuted design allowed us to mimic the trimerization functionality of the E1 TMD by fusing the I53-50A trimerization domain to the C-terminus of E1 (E2E1-I53-50A) 46