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En modelos animales preclnicos, dado su carcter de molcula pequea oral-activa, los diseos han contemplado dosificacin por va oral o intraperitoneal segn el protocolo aprobado por el comit de tica institucional, con esquemas de administracin diaria y ventanas de tratamiento que abarcan varias semanas para observar efectos sobre composicin corporal

Semete, B

Meyer et al., 2008)

We employed targeted and untargeted metabolomics of human plasma and a mice model to investigate metabolites linked to gallstone disease and gallbladder cancer as potential biomarkers

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