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As the H-2Kq antibody recognises properly assembled, peptide-loaded MHC class I complexes, this reduction likely reflects a functional impairment of Class I antigen presentation capacity

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In a circadian misalignment model (mice kept in the dark for 14 days) in which lower SIRT1 activity was observed, SIRT1 overexpression led to improved insulin sensitivity [31]

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However, we found that it is virtually fully oxidized, when expressed in the periplasm, suggesting that its engineered cysteine residues are completely oxidized by the oxidative folding machinery

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The reaction was started by adding 1.0 mL of 200 mM hydrogen peroxide (H 2 O 2 ) in the test cuvette and by adding the same volume of distilled water instead of hydrogen peroxide in the reference cuvette

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Tumor-infiltrating lymphocytes in the immunotherapy era

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