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116 MftogluM.ElibolB.DalmizrakO.ErcanA.KulaksizG.OgsH.et al (2004)

Intrathecal administration ensures that tofersen targets motor neurons with pinpoint accuracy through cerebrospinal fluid, effectively diminishing cerebrospinal levels of SOD1 protein and plasma levels of neurofilament light chainsbiomarkers that signal the regression of neuronal damage (43)