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Reviewer 1 While the authors quantified cell proliferation of (or rather density of proliferating) RGL-NSCs and IPCs 3 weeks after TAM using EdU to label proliferating cells, this is an (understandably) narrow outcome measure in that it only assesses EdU labeled cells

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For best results, a series of 6 treatments is completed in 3 weeks, providing 2 treatments per week

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The result is a solution of known concentration, expressed in milligrams per millilitre (mg/mL)

Additionally, it also discusses mitochondria-related signaling pathways in AP and proposes potential therapeutic strategies targeting mitochondrial dysfunction for improved AP diagnosis and treatment