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PLoS ONE 6:e23502

The structural site has been shown to be important for maintaining the long term stability of the enzyme

If a Sulfanomide allergy we continue with thiol therapy but start low in case they are one of those cross reactors (which is rare but not unheard of).

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Oral antibiotics can inhibit the increase of TMAO level after stimulation of the choline or carnitine diet, suggesting that intestinal bacteria are required for TMAO production (Wang et al., 2011