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Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)

INSTRUCTIONS FOR USE Take one capsule with a glass of water/juice to aid swallowing

Improves skin radiance

Consume one tablet once daily, or as directed by a healthcare professional

Peer review Peer review information Nature Reviews Molecular Cell Biology thanks Charles Brenner, Evandro Fang and Lindsay Wu for their contribution to the peer review of this work