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Tetrahydrofolate (THF) serves as a universal one-carbon acceptor and can accept one-carbon from the conversion of serine to glycine (folate cycle), the oxidation of glycine to CO 2 and NH 3 by the glycine cleavage system (GCS) 6 or methionine to homocysteine conversion (methionine cycle) 59

Endocrinol Exp 10(4):289295 Guan ZZ, Zhuang ZJ, Yang PS, Pan S (1988) Synergistic action of iodine deficiency and fluorine intoxication on rat thyroid

Fibroblast growth factors (FGFs), such as FGF21, show circadian expression and support vascular repair by enhancing VEGF signaling and promoting the activity of endothelial progenitor cells (EPCs) (86, 87).Together, these data suggest that therapeutic strategies targeting both clock components (CLOCK/BMAL1 or PER/CRY) and angiogenic factors (VEGFA/FGF) could enhance BBB recovery and improve outcomes after stroke

10.1021/bi00109a007 30 HayesJ

Neurotypical control participants were eligible if they had no history of neurological or developmental disorders, no first-degree relatives diagnosed with ASD and were in good overall physical and mental health at the time of recruitment, as reported by parents or legal guardians

R., and Nygard, O