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Possible concerns encompass herbdrug interactions (e.g., botanical substances influencing cytochrome P450 enzymes), ocular surface toxicity resulting from extended use of certain extracts or preservatives in formulations, and systemic adverse effects from oral supplementation

Some patients may not be appropriate candidates based on active conditions, medication use, or other medical factors

Pre- and post-treatment of kindled rats with either GbE or LC significantly alleviated the changes in monoamine (NE, DA, and 5-HT) levels in the rats hippocampus and hypothalamus