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Siemes H, Nau H, Schultze K, Wittfoht W, Drews E, Penzien J, Seidel U: Valproate (VPA) metabolites in various clinical conditions of probable VPA-associated hepatotoxicity

These molecules further activate the nuclear factor-kappa B (NF-kB) pathway, which perpetuates proinflammatory destruction in the CNS, muscle, and neuromuscular junction [237]

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This metabolic shift forces cells to rely more on glycolysis to support biosynthesis, while upregulating fatty acid transporters to enhance the uptake of exogenous fatty acids [20, 21]

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