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A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

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doi: 10.1016/j.xgen.2023.100457 127 JiEBoerrigterDCaiHQLloydDBruggemannJODonnellMet al

The microscopy images showed cell rupture and lysis (H&E stain), indicative of signs of cell death (TUNEL stain) in the tumor tissue (Fig

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