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Data management & statistical analysis Sample size calculations were based on previous oral wound healing study outcomes for CWE prevalence on day 7 [25], and indicated that a study with 22 participants (11 per group) would have 80% power, at 5% significance level (two-sided), to detect a significant difference between the two groups, assuming a 55% difference in CWE incidence

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Rahali D, Dallagi Y, Hupkens E, Veegh G, Mc Entee K, Asmi ME

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