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Granulocyte colony-stimulating factor receptors on granulocytes are down-regulated after endotoxin administration to healthy humans

27 In a study not included in these meta-analyses, Frimberger et al

44, e13316

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compound 7 ) was bioactivated to an ortho -quinone in dog liver microsomes as evident from the formation of the corresponding GSH conjugate, and moreover, 7 was hepatotoxic in chronic dog safety studies in a manner similar to 1 , further strengthening the link between bioactivation and the observed hepatotoxicity