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Few investigations incorporated clinically relevant comparators, standardized rehabilitation conditions, or endpoints directly translatable to postoperative recovery

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Results: Fifty-four patients were included: 35 CAA-ICH+ and 19 CAA-ICH- (male 62.86% vs 47.37%, p = 0.42, mean age 63.37 vs 67.79, p = 0.13, respectively)

A series of investigative studies were conducted in dogs to determine the optimal absorption window for hydrocortisone, enabled by multi-particulate formulations with a significantly shortened sustained-release phase such that the majority of the drug payload would be released in the small intestine

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