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Wu LH, Huang BR, Lai SW et al (2020) SIRT1 activation by minocycline on regulation of microglial polarization homeostasis

Under healthy conditions, microglia have long branches that are used for moving and surveying the surrounding area for pathogens

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Nonetheless, translation of sulfide-based therapy to clinical practice has been stymied due to the very low therapeutic index of sulfide and the incomplete understanding of endogenous sulfide metabolism

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In summary, the literature predominantly aligns with Level 2 and Level 3 evidence, reflecting a considerable degree of scientific rigour