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However, excessive ROS not only damages host cells, causing oxidative stress, but also chronically activates immune cells, forming a vicious cycle of ROS overproduction

9,10,11,16 It has also been suggested that withanolides are hormone precursors and that ashwagandha acts as an amphoteric, that is it can bind to hormone receptors and exert a mild effect where hormone levels are low, while blocking the receptor when hormone levels are too high

McIntyre M, Bohr DF, Dominiczak AF