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328 In ALS, HSBP8 protects against aggregation of TDP-43 and its cleavage products (TDP-25 and TDP-35) by promoting their removal via autophagy, further illustrating the tight functional coupling between sHSPs and degradative pathways

Both ALA and its reduced form DHLA act as potent antioxidants, capable of scavenging reactive oxygen species in various cellular compartments

cDNA synthesis was performed with the PrimeScript RT Reagent Kit (Takara, RR047A, Japan)

doi: 10.1016/j.bmcl.2014.11.062

These results conclusively demonstrate that, in the absence of NTRC, a portion of GSAAT At remains in the oxidized form

The accumulation of iron in the brain may induce lipid peroxidation through oxidative stress, potentially triggering ferroptosis