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10.1007/s00114-015-1318-z

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

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The first clinical trial of ambroxol in PD demonstrated its ability to cross into the cerebrospinal fluid and increase glucocerebrosidase protein levels regardless of the presence of GBA1 mutations [180]

It has been studied for tissue repair and inflammation in many animal models

Circulating IGFBPs, especially IGFBP-3 and IGFBP-5, can combine with circulating IGFs and acid-unstable subunits produced by liver cells to create terpolymer complexes around 140 kDa, resulting in a prolonged half-life of IGFs in circulation that can slow down the movement of IGFs to tissues outside of blood vessels [89, 90]