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The absence of resistance induction upon KEAP1 inhibition in SCLC cells was unexpected, given that ROS-induced inactivation or genetic loss of KEAP1 is a common mechanism of resistance to redox-targeting drugs in many cancer types 27

The other non-perfused brain regions were snap frozen in 80 C 2-methylbutane and stored in a 80 C freezer until further processing for protein extraction

Multiple alternatively spliced transcript variants encoding different isoforms have been found.Synonyms: GLUR, GR, GRD1, GRase, GSR Molecular Weight 56257 Da Gene ID 2936 NCBI Accession NP_000628 Pathways Thyroid Hormone Synthesis, Cell RedoxHomeostasis Target