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YW and RW revised the manuscript and provided critical advice on the content of the manuscript

Xu R, Wang Q, Li L (2015) A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat

Importantly, SCFA production is not limited to conventional probiotics

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hallii , Blautia obeum , Flavonifractor plautii , Ruminococcus gnavus , and Klebsiella pneumoniae were found to also grow in the presence of 1,2-PD (Fig

NAD+ helps hundreds of biochemical reactions, so its decrease affects nearly every aspect of cell function