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Infertility: Inform males of reproductive potential that IBRANCE may cause infertility and to consider sperm preservation before taking IBRANCE [see Use in Specific Populations (8.3)]

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Clinical studies consistently demonstrate a high prevalence of mental disorders among CVD patients, with depression affecting 20% - 30% of post-myocardial infarction cohorts and conferring a 2-fold increased mortality risk (HR = 2.24, 95% CI 1.85 - 2.71) [81]