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GI cancers arise from complex mechanisms involving chronic inflammation, genetic mutations, and disrupted signaling pathways that promote uncontrolled cell growth and metastasis

Recognizing the essential function of selenoproteins, such as glutathione peroxidase and thioredoxin reductase, in antioxidant defense and in preserving a reduced intracellular state, selenium is able to expedite the DNA repair process

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In fact, one of the first signs of vitamin B12 deficiency is fatigue

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Yes, in research designed around stress and cognition together though they engage different primary mechanisms, so they're typically studied in parallel arms rather than as a combination