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Acetaldehyde itself is 1030 times more toxic than ethanol, binding to proteins and DNA to form adducts that trigger inflammatory responses

8 Although animal dermatosparaxis was the first recognized collagen disorder, it took more than 20 years to confirm the existence of a human counterpart for the disorder

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430 A 2023 systematic review and meta-analysis indirectly compared the risk of non-major bleeding events of different DOACs using data from 19 randomized controlled trials involving 85,826 participants with atrial fibrillation

For example, interaction with atractylenolide I led to increased oral Cmax and systemic plasma exposure of AS-IV (Song et al., 2014)