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The highest resolution achieved in cryo-EM for protein structure determination is currently 1.25 (as reported for apoferritin, which is composed of 24 subunits arranged in a symmetrical structure, with a total molecular mass of 440480 kDa) (Yip et al., 2020)

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Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre