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If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation (safely switching the patient to a different opioid moiety) (see DOSAGE AND ADMINISTRATION, WARNINGS)

10.1038/s41591-025-03867-5 137 SantoniM.MassariF.AmantiniC.NabissiM.MainesF.BurattiniL.et al (2013)

Another recent paper demonstrates the simultaneous synthesis of both thioesters and FeS clusters in water, yet the resulting clusters are likewise coordinated by peptide molecules 24