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To this end, we applied decreasing concentrations of the A-anticalin to the CA1 hippocampal area of non-plaque-bearing APP23 mice, a model of early AD, which, due to the lack of the PS mutation, develops plaques at a later age 25

This is an illustrative pattern, not a dosing schedule adapt the number of sites to how often a given research protocol is administered

Of particular importance is the exposure of PS on the outer leaflet as it is a strong marker for cell eryptosis (Nguyen et al., 2011

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PubMed, doi:10.1093/ajcn/87.3.753