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This mechanism facilitates the spread of A from platelets into the bloodstream and eventually into the brain tissue, adding to the overall amyloid accumulation (131, 135)

Paraptosis: a unique cell death mode for targeting cancer

As a final note, some studies have reported the emergence of sleep-like electrophysiological features in awake animals (Souza et al., 2024

Both types of PE-AA oxidation, enzymatic (by lipoxygenase) and non-enzymatic (by autooxidation to PE-AA-OOH), eventually result in cell death [18, 30,31,32]

There was evidence for glutathione oxidation during the reduction of dehydroascorbate (DHA) involving GSTO2 (ref

This enzyme converts 25-hydroxyvitamin D to active calcitriol, leading to increased intestinal calcium absorption and hypercalcemia