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Degradation of perilipin is mediated through ubiquitination-proteasome pathway

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Alzheimers Disease and Parkinsons Disease Vitamin B12 levels in the low-normal subclinical range (250 mol/L) are associated with Alzheimers disease, vascular dementia, and Parkinsons disease

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The choice to analyze the intracellular protein concentrations of IL-1B and CCL3 was based on the premise that the inhibition of gene transcription in response to B12 added to the turnover of these proteins by the proteasome machinery present inside the cells would result in detectable reductions in their concentrations after 24 hours of culture incubation