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A3, the conditioner and the denoiser are trained together, minimizing the mean square error (MSE), feeding the network with random patches of ERA5 predictors (64 64 pixels) and static data (512 512 pixels) for the conditioning and high-resolution target variables (512 512 pixels) for the ground truth

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While preclinical and early-phase trials of cyclosporine A have shown promise, a larger phase III clinical trial (the CIRUS clinical trial of patients with acute anterior ST-segment elevation myocardial infarction given cyclosporine before undergoing percutaneous coronary intervention) has not been as successful 39,40