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doi: 10.1007/978-1-4471-3879-2_1 20

Differentgradingsystems based on MRI scans such as Schizas, Braz, and Lees grading systems can help provide diagnostic accuracy and guide the decision as to whether surgery is necessary

J Transl Med 13:326

Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions