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Therefore it may be speculated that induction of IGFBP-5, which is pro-apoptotic in some cancers [17], may be an important function of miR-193 downregulation in tumor suppression

The concept of two hormones and one receptor to explain the different actions of androgens has been generally accepted and, according to the information available from the human genome project, it is very unlikely that additional genes exist coding for a functional nuclear receptor with androgen receptor-like properties (25)

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