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These findings highlight the critical role of the INS locus in central tolerance and demonstrate that genetic variants can impact both disease risk and progression, underscoring the need to investigate other non-HLA genes associated with T1D

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Building on these reviews, this study proposes a conceptual framework for spatial circularity, structured around three interrelated components: (1) local circularity as the core, providing the socio-spatial foundation for integrating CE principles into urban contexts

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