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Zhang B, Liu SQ, Li C, Lykken E, Jiang S, Wong E, et al

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TQ (35 mg/kg/day, p.o., 3 days/week for 9 weeks) enhanced cytotoxicity of 5-fluorouracil in AOM-instigated colon cancer rats by reducing expressions of Wnt, -catenin, NF-B, VEGF, COX2, iNOS, and TBRAS and upregulating expressions of TGF-1, TGF-/RII, Smad4, DKK-1, cyclin-dependent kinase inhibitor (CDKN)1-A, and GPx [118]