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The cells were washed three more times with 1X DPBS, air dried, and mounted with ProLongGold TM antifade reagent (Cell Signaling, 9071S) on glass slides

Author Contributions Conceptualization, S.K.A

The hypothesis of oxidative stress highlights the crucial role of antioxidant defenses as an important component of the overall redox balance of the organism

This indicates that the brain, with its high and specific energy demands, might respond differently to metformins metabolic reprogramming compared to other tissues, potentially leading to energy deficits or altered neuronal function under certain conditions, particularly in non-diabetic individuals or those with already compromised neuronal bioenergetics