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Although the results are limited due to a very small number of studies and patients, an ongoing phase 2 TOP-CKD trial (NCT04258397) that aims to recruit 200 participants and will be completed by December 2024, will hopefully provide additional evidence of the efficacy of pirfenidone as treatment for kidney fibrosis

More structural changes like meaningful wrinkle reduction or improved jaw definition take longer, typically 10 to 16 weeks of consistent use

Ipamorelin may cause mild water retention or bloating in some patients because growth hormone signaling affects fluid balance

Myostatin is a protein the body produces specifically to limit muscle growth beyond a genetically determined ceiling

Supplements support your health but do not replace a balanced diet