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Gut inflammation, low stomach acid, individual digestive health, and competing medications all reduce how much actually absorbs typically somewhere between 20% and 50% of the dose

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HIM 2021 Flores etal Association of plasma concentration of vitamin B12 with All-Cause mortality in the general population in the Netherlands JAMA 2020 3 e1919274 Lacombe V, Chabrun F, Lacout C, Ghali A, Capitain O, Patsouris A, Lavigne C, Urbanski G

Reversible peripheral neuropathy induced by vitamin B12 deficiency The rationale behind most symptoms resolving within 3 months is simple: B12 supplementation results in a swift increase of immature red blood cells within the initial 2-3 days, followed by a gradual normalization of anemia over a 3-month period