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These disorders frequently present with depression and anxiety symptoms due to shared neural, inflammatory, and biochemical mechanisms (Ray and Agarwal, 2020

This effect is associated with the secretion of L-Malic acid (MA), which polarizes anti-inflammatory M2 macrophages and restores interleukin-10 levels through the action of SOCS2[36]

Royal College of Physicians (Edin)

Jung et al., Infarcted myocardium-primed dendritic cells improve remodeling and cardiac function after myocardial infarction by modulating the regulatory T cell and macrophage polarization